Jason Calcanis gave the opening keynote at the PME. At least it was billed as a keynote. If I had to categorize it, I'd say it was more of a stand-up routine. He was pretty funny.
During his keynote, Jason analyzed different entreprenurial opportunities in podcasting using sounds from Pacman. He probably upset a few folks in the room as he ticked off the areas in podcasting to avoid including directory services, search and advertising.
His advice was to find the areas that caused the most pain and move forward from there.